Share

News & Articles

General Vaccine Safety Studies


Demographic characteristics of members of the Vaccine Safety Datalink (VSD): A comparison with the United States population.

August 26, 2015

Sukumaran et al. Vaccine

The Vaccine Safety Datalink (VSD) is a collaboration between CDC and nine integrated health care systems that serves as a cornerstone of US post-licensure vaccine safety monitoring. Given concerns that potential differences between the insured VSD population and the US population could limit the generalizability of VSD study findings, this paper performed a comparison of the demographic characteristics between the two populations.



Safety of Vaccines Used for Routine Immunization of US Children: A Systematic Review.

June 1, 2014

Maglione et al. Pediatrics

Concerns about vaccine safety have led some parents to decline recommended vaccination of their children, leading to the resurgence of diseases. Reassurance of vaccine safety remains critical for population health. This study systematically reviewed the literature on the safety of routine vaccines recommended for children in the United States.



More General Vaccine


Studies about Pertussis and Tdap/DTap


Association of Tdap Vaccination With Acute Events and Adverse Birth Outcomes Among Pregnant Women With Prior Tetanus-Containing Immunizations

October 20, 2015

Sukumaran et al. JAMA

Pertussis is poorly controlled, with the highest rates of morbidity and mortality among infants. Although the source of infant pertussis is often unknown, when identified, mothers have historically been the most common reservoir of transmission. Despite high vaccination coverage, disease incidence has been increasing. The authors examined whether infant source of infection (SOI) has changed in the United States in light of the changing epidemiology.



Sources of Infant Pertussis Infection in the United States

September 1, 2015

Skoff et al. Pediatrics

Pertussis is poorly controlled, with the highest rates of morbidity and mortality among infants. Although the source of infant pertussis is often unknown, when identified, mothers have historically been the most common reservoir of transmission. Despite high vaccination coverage, disease incidence has been increasing. The authors examined whether infant source of infection (SOI) has changed in the United States in light of the changing epidemiology.



More Pertussis & Tdap/DTap


Studies Examining the Reduction of Disease Burden


Seasonal Trivalent Influenza Vaccination During Pregnancy and the Incidence of Stillbirth: Population-Based Retrospective Cohort Study

April 1, 2016

Regan et. al Clinical Infectious Diseases

Mothers who received seasonal TIV during pregnancy were significantly less likely to experience stillbirth compared with unvaccinated mothers. These results support the safety of seasonal influenza immunization during pregnancy and suggest a protective effect.



The Benefit of Early Influenza Treatment of Pregnant Women Hospitalized with Laboratory Confirmed Influenza

February 4, 2016

Oboho et al. The Journal of Infectious Diseases

Pregnant women are at higher risk for serious illness and complications, including death, from influenza. For expectant mothers hospitalized with flu, early treatment with the influenza antiviral drug oseltamivir may shorten their time in the hospital, especially in severe cases, suggests a study published in The Journal of Infectious Diseases. The findings also underscore the importance of flu vaccination for this risk group.



More on Disease Burden


Measles-Mumps-Rubella (MMR) Vaccine and Autism Studies


Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism

May 21, 2015

Jain et al. JAMA

To report ASD occurrence by MMR vaccine status in a large sample of US children who have older siblings with and without ASD the authors did a retrospective cohort study using an administrative claims database associated with a large commercial health plan. Participants included children continuously enrolled in the health plan from birth to at least 5 years of age during 2001-2012 who also had an older sibling continuously enrolled for at least 6 months between 1997 and 2012.



Safety of Vaccines Used for Routine Immunization of US Children: A Systematic Review.

August 1, 2014

Maglione et al. Pediatrics

Concerns about vaccine safety have led some parents to decline recommended vaccination of their children, leading to the resurgence of diseases. Reassurance of vaccine safety remains critical for population health. This study systematically reviewed the literature on the safety of routine vaccines recommended for children in the United States.



More MMR & Autism


Thimerosal and Autism Studies


Administration of thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology

October 6, 2015

Gdad et al. PNAS

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Some anecdotal reports suggest that ASD is related to exposure to ethyl mercury, in the form of the vaccine preservative, thimerosal, and/or receiving the measles, mumps, rubella (MMR) vaccine. Using infant rhesus macaques receiving thimerosalcontaining vaccines (TCVs) following the recommended pediatric vaccine schedules from the 1990s and 2008, we examined behavior, and neuropathology in three brain regions found to exhibit neuropathology in postmortem ASD brains. No neuronal cellular or protein changes in the cerebellum, hippocampus, or amygdala were observed in animals following the 1990s or 2008 vaccine schedules. Analysis of social behavior in juvenile animals indicated that there were no significant differences in negative behaviors between animals in the control and experimental groups. These data indicate that administration of TCVs and/or the MMR vaccine to rhesus macaques does not result in neuropathological abnormalities, or aberrant behaviors, like those observed in ASD.



Prenatal and Infant Exposure to Thimerosal From Vaccines and Immunoglobulins and Risk of Autism

September 13, 2010

Price et al. Pediatrics

Exposure to thimerosal, a mercury-containing preservative that is used in vaccines and immunoglobulin preparations, has been hypothesized to be associated with increased risk of autism spectrum disorder (ASD). This study was designed to examine relationships between prenatal and infant ethylmercury exposure from thimerosal-containing vaccines and/or immunoglobulin preparations and ASD and 2 ASD subcategories: autistic disorder (AD) and ASD with regression.



More Thimerosal/Autism


Institute of Medicine (IOM) Reports


Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies

January 16, 2013

The Institute of Medicine (IOM) of the National Academies

This report is the most comprehensive examination of the immunization schedule to date. The IOM committee uncovered no evidence of major safety concerns associated with adherence to the childhood immunization schedule. Should signals arise that there may be need for investigation, however, the report offers a framework for conducting safety research using existing or new data collection systems.



Adverse Effects of Vaccines: Evidence and Causality

August 25, 2011

The Institute of Medicine (IOM) of the National Academies

Using epidemiologic and mechanistic evidence, the committee developed 158 causality conclusions and assigned each relationship between a vaccine and an adverse health problem to one of four categories of causation:

  • Evidence convincingly supports a causal relationship
  • Evidence favors acceptance of a causal relationship
  • Evidence favors rejection of a causal relationship
  • Evidence is inadequate to accept or reject a causal relationship

The committee finds that evidence convincingly supports a causal relationship between some vaccines and some adverse events—such as MMR, varicella zoster, influenza, hepatitis B, meningococcal, and tetanus-containing vaccines linked to anaphylaxis. Additionally, evidence favors rejection of five vaccine-adverse event relationships, including MMR vaccine and autism and inactivated influenza vaccine and asthma episodes. However, for the majority of cases (135 vaccine-adverse event pairs), the evidence was inadequate to accept or reject a causal relationship. Overall, the committee concludes that few health problems are caused by or clearly associated with vaccines.



More IOM Reports


RECENT CONVERSATIONS

Amy Pisani @ EveryChildBy2
We don't rec medical advice from celebs but appreciate their support of evidence based med & vaccines @TODAY_Parent https://t.co/J3Wcybe10R
Amy Pisani @ EveryChildBy2
Real threat to Nat'l security is 18% budget cut to NIH, 28% to depts that prevent disease outbreaks & much more. https://t.co/n8kfpG5mfq
Amy Pisani @ EveryChildBy2
RT @DrNancyM_CDC: Hear this pediatrician & parent explain why she recommends #HPV vax for boys & girls age 11-12. https://t.co/LhfaPXgz2U
Amy Pisani @ EveryChildBy2
The power of data: @healthmap disease surveillance data helps explain the mystery of the rise in #mumps cases https://t.co/io0jFACggV
Amy Pisani @ EveryChildBy2
Can a new powered rotavirus vaccine save 100,000 children each year? via @NPR https://t.co/A0fujkA6xF
Amy Pisani @ EveryChildBy2
As #healthcare & #budget #reform cont on the #Hill people must contact legislators to emphasize value of #vaccines https://t.co/sdkk9PGE3f
Amy Pisani @ EveryChildBy2
Kids need #flu vaccine every yr. Life got busy. Vaccination fell off priority list. Then Caroline nearly died. https://t.co/IiMz197EcU
Amy Pisani @ EveryChildBy2
RT @NYTHealth: Rotavirus kills about 600 children a day. A new vaccine could do a better job of controlling it. https://t.co/X7PxZ0ySJz
Amy Pisani @ EveryChildBy2
Study shows #shingles #vaccine 57% effective in preventing pain in 3 yrs post vaccination. Get vaccinated at 60+.… https://t.co/IslBrFGMzD
Amy Pisani @ EveryChildBy2
You never know where measles is lurking. CA resident w/ #measles exposes others at 2 different medical facilities.… https://t.co/q8GVb0XUmW
Amy Pisani @ EveryChildBy2
Getting vaccinated while #pregnant is critical in protecting both Mom & baby from #flu & #pertussis. #VaccinesWork https://t.co/rruLuthcuf
Amy Pisani @ EveryChildBy2
Dr @AHalladayASF: #vaccine #autism myth perpetuated by celebrities & politicians is distraction from real science https://t.co/ZU1MAJj2uB
Amy Pisani @ EveryChildBy2
RT @bylenasun: Trump budget proposes new federal emergency fund proposed to respond to public health outbreaks. https://t.co/swiqyfzKax
Amy Pisani @ EveryChildBy2
Ever wonder if #flu vaccines are effective for kids under 2? Well, they are! Thanks @pedsgeek for all the data at https://t.co/kcs4dY2cvj
Amy Pisani @ EveryChildBy2
HHS Sec suggests #vaccine mandates should be decided in state. Time for public to make voices heard at state level https://t.co/K99pOQEwHD
Amy Pisani @ EveryChildBy2
RT @bylenasun: Proposed cuts to HHS budget would send spending to lowest levels in almost 2 decades. https://t.co/lXA4u5jaaG
Amy Pisani @ EveryChildBy2
Study shows the reasons parents give for not getting their kids the #HPV #vaccine seem to be changing over time. https://t.co/dcnvO59ymG
Amy Pisani @ EveryChildBy2
Colorado childhood immunization rates have risen from 50% in the 1990s to 75% today, but still room for improvement. https://t.co/jVqLK1AejI
Amy Pisani @ EveryChildBy2
FDA Committee selects 2017-2018 Influenza #vaccine strains. Backs@WHO recommendations https://t.co/N1WSLGOxbc #Flu
Amy Pisani @ EveryChildBy2
Another informative article from @DrPaulOffit in @thedailybeast. This week explaining recent #mumps outbreaks. https://t.co/CXxbYWm9wu
Amy Pisani @ EveryChildBy2
Relieved Trump's FDA pick agrees #vaccine - #autism theories have been thoroughly debunked & it's time to move on. https://t.co/0jzCoI9Zng
Amy Pisani @ EveryChildBy2
This year's #flu season: it's not over till it's over & it's not over! Sadly 48 kids have died so far this season! https://t.co/WTZXYr1C6v
Amy Pisani @ EveryChildBy2
Should parents know the vaccination rates at their kids' schools. This editorial writer from TX believes so! https://t.co/86r9guom6T
Amy Pisani @ EveryChildBy2
TY @nphic for sharing our #StateoftheImmUnion Report. Hoping lots of public health advocates will download at https://t.co/X6lxswLyW5
Amy Pisani @ EveryChildBy2
If we want to save $ boosting #vaccine uptake is a good place to start! More details in our #SOTI report at… https://t.co/hwf3BGGaC6
Amy Pisani @ EveryChildBy2
Anyone whose had #shingles can tell you how painful it us. Vaccination rates are low & racial disparities also inte… https://t.co/dSv74Uhq8T
Amy Pisani @ EveryChildBy2
RT @DrNancyM_CDC: Ob-gyns & midwives: Don’t carry Tdap in your office? See CDC’s tips for making a strong vaccine referral. https://t.co/NJ
Amy Pisani @ EveryChildBy2
RT @DrNancyM_CDC: #Clinicians, when you talk w/ parents about #HPV vaccine, which vaccine message resonates best with parents?
Amy Pisani @ EveryChildBy2
RT @sarahdespres: How much do #vaccine preventable illnesses cost us? A lot! TY to @EveryChildBy2 for this report https://t.co/RTn5oGZnSB
Amy Pisani @ EveryChildBy2
.@POTUS can save by investing in #vaccines. Preventable diseases cost $578mil a yr https://t.co/N8jsiLGdMOhttps://t.co/osTBKOToHe
Amy Pisani @ EveryChildBy2
Our #StateoftheImmUnion Report highlights key challenges we must address for optimal public health.… https://t.co/dCGOguUs4R
Amy Pisani @ EveryChildBy2
Our #StateoftheImmUnion report sent to Congress to help address nation's top public health threats.… https://t.co/5B3KtUuhWa
Amy Pisani @ EveryChildBy2
Special report on #StateoftheImmUnion sent to Congress re monetary/societal value of #vaccines.https://t.co/qGa3I12JAx
Amy Pisani @ EveryChildBy2
Only 2% of Americans refuse #vaccines but this tiny group may be creating public health problems that impacts us all https://t.co/qsmXAXONwZ
Amy Pisani @ EveryChildBy2
RT @DrNancyM_CDC: CDC’s #PreteenVaxScene Webinar series now all online. Find recordings to past webinars at: https://t.co/BkbA5hfGDj.
Amy Pisani @ EveryChildBy2
The fact that #HPV is associated w/ sex is keeping parents from protecting kids from deadly HPV-related cancers. https://t.co/eBDoj9kTKZ
Amy Pisani @ EveryChildBy2
KS bill requires kids get meningitis #vaccine. Hoping will help improve low 60% vax rate in #Kansas kids 13-17. https://t.co/swrdFm4GXl
Amy Pisani @ EveryChildBy2
RT @sabinvaccine: A3: Cost of new vaccine intro is rising and countries need to be able to support themselves upon Gavi graduation. #Immuni